Adult Progenitors in Kidney Tubulointerstitium

Key Personnel

Benjamin D. Humphreys (PI)
Washington University in St. Louis

• Monica Chang-Panesso
  Washington University in St. Louis
• Eoghainin OhAinmhire
  Washington University in St. Louis
• Haojia Wu
  Washington University in St. Louis

Project Description

We are interested in the capacities of adult kidney progenitor cells to model the kidney interstitium. Our project focuses on two such populations, a resident mesenchymal stem cell population characterized by expression of Gli1, and dedifferentiated tubular epithelial cells defined by expression of Havcr-1. We will isolate these cell types, define their differentiation capacity in vitro, and coculture them in collaboration with other RBK investigators to model the kidney interstitium in 3D.