Single-nuclei multiome atlas for a mammalian model of kidney regeneration

Key Personnel

Project Description

Seeks to investigate mechanisms for kidney tissue regeneration by understanding how gene expression is modified through epigenetic changes in the spiny mouse, a model animal that can regenerate kidney tissue. In completing this proposed research, the milestone to be achieved is a robust dataset that associates regions of open chromatin based on single nuclei ATAC-sequencing with gene expression levels based on single nuclei RNA-sequencing data for individual cell types in a regenerating spiny mouse kidney after ischemia-reperfusion injury.